Serum Sickness-like Reaction induced by Antituberculous Drugs

Tuberculosis verrucosa cutis is a rare form of tuberculosis and it is typically seen as a chronic verrucose plate. At the first stage treatment of disease, rifampicin, isoniazid, pyrazinamide and ethambutol are quite effective. However, side effects developing due to antituberculosis drugs can cause a significant level of morbidity and mortality. Cutaneous medicine reactions are among major side effects being widely observed. Serum sickness-like reaction is a rare immunologic disease that can develop as relating with medicines such as penicillins, cephalosporins and trimethoprim-sulfamethoxazole. It is defined as type III hypersensitive reaction that classically develops against heterologous proteins. Its real mechanism could still not be fully understood. In this case presentation, we are introducing a female patient aged 28 who developed a serum sickness-like reaction following antituberculosis treatment.