Photocontact Dermatitis due to Hypericum perforatum

Hypericin, originating from Hypericum perforatum, is a potent photosensitizer known to induce skin phototoxicity when given systemically. Hypericum perforatum is a botanical extracts with anti-inflammatory and antibacterial effect. Photocontact dermatitis is a common cutaneous reaction by various herbs. We describe a 54-year-old female patient with Hypericum perforatum associated photocontact dermatitis shortly after topical application therapy for knee pain due to osteoarthritis. Hypericum perforatum therapy was stopped and the patient was treated with topical corticosteroids and systemic antihistamines. The eruption resolved within ten days. Photocontact dermatitis induced by Hypericum perforatum has been reported as second case in English literature. We propose that photocontact dermatitis is a side-effect of topical Hypericum perforatum.